Project 8

Development of bioactive compounds to modulate NETs by targeting GAS6-TAM receptors

Host institute: Université Paris Cité, France (UP)
Supervisor: Dr Nadia Soussi-Yanicostas (UP)
Co-supervisor: Dr Peter Timmerman (BS)

Objectives
1. To proof the concept GAS6 is a promising mediator of NET removal.
2. To develop novel bioactive compounds small compounds and peptides to regulate the GAS6-TAM system.
3. The identified compounds will be experimentally tested (in vitro and in vivo) by the Doctoral Candidate of project 4 (DC4).

Expected Results
Identification and development of novel modulators of GAS6-TAM function.

Secondments
- IIBB (3 months)
- UMA (3 months)
- BasicPharma (1 month)

Requirements
Qualifications: Master in Science (MSc) equivalent to Master 2 (or equivalent), English B2 or above. The chosen applicant will be processed through the university application system and require the institution board approval prior to acceptance for doctoral studies.
Experience: Minimum of four years undergraded studies within the field of cell biology, immunology, and molecular biology. The applicant should also have experience in different basic methodology within the research field.
Knowledge & skills: The applicant should have basic knowledge in how to conduct in vivo experiments on animal models and knowledge in basic statistics. A knowledge in the zebrafish model will be an asset without being a determining element. Similarly, a knowledge in standard methods (In vivo imaging, PCR/RT-PCR, Seahorse, Imaris, etc) will also be an asset without being mandatory. Good animal Practice and Good Laboratory Practice course certificate are also an asset.
Abilities: In abundance to the aforementioned requirements, the applicant should possess the ability to successfully conduct literature studies i.e., retrieve, critically review, analyze, and summarize literature. The applicant should be fluent in English in both writing and speech and have good communication abilities. The ability to independently plan experimental studies is meritorious.
Attitude and disposition: The Praetorian MSCA doctoral network requires abundant traveling and social settings. The applicant should be willing to present research orally and in writing, socialize and network at meetings within the consortium but also at major international conferences and at the home institution. The applicant is expected to voluntary contribute to the science community including engaging in scientific communities and PhD-communities at University Paris-Cité.