Project 10

Single or multiple therapy - what is the optimal approach to tackle sepsis?

Host institute: Uppsala Institutet, Sweden (UU)
Supervisor: Dr Stephanie Franzén
Co-supervisor: Prof. Chris Reutelingsperger (PT)

Objectives
1. To investigate the efficient approach to treat sepsis in related animal models by comparison of using single inhibitor and combined inhibitors (targeting multiple pathways) together with antibiotics.
2. The novel inhibitors derived from Work Package 2 will be used and tested by the Doctoral Candidate.

Expected Results
Proof-of-concept: Improvement of the treatment of sepsis by targeting DAMPs and NETs which will pave a way to personalized medicine for sepsis therapy.

Secondments
- IIBB (3 months)
- WWU (3 months)

Requirements
Qualifications: Master in Science (MSc) or Medical Doctor degree (MD) equivalent to 240 credits, Felasa C certificate (or equivalent), English B2 or above. The chosen applicant will be processed through the university application system and require the institution board approval prior to acceptance for doctoral studies.
Experience: Minimum of four years undergrad studies within the field of biomedicine, medicine, or cell biology. The applicant should have experience in different basic methodology within the research field.
Knowledge & skills: The applicant should have basic knowledge in how to conduct in vivo experiments on animal models and knowledge in basic statistics. Good knowledge in standard in vitro analytical methods is meritorious (PCR, Western, ELISA, etc). Experience in experimental large animal models or clinical studies is commendable. Good Clinical Practise (GCP) and Good Laboratory Practise (GLP) course certificate are highly meritorious.
Abilities: In abundance to the aforementioned requirements, the applicant should possess the ability to successfully conduct literature studies i.e., retrieve, critically review, analyze, and summarize literature. The applicant should be fluent in English in both writing and speech and have good communication abilities. The ability to independently plan experimental studies is meritorious.
Attitude and disposition: The Praetorian MSCA doctoral network requires abundant traveling and social settings. The applicant should be willing to present research orally and in writing, socialize and network at meetings within the consortium but also at major international conferences and at the home institution. The applicant is expected to voluntary contribute to the science community including engaging in scientific communities and PhD-communities at Uppsala University.